Gary Sinise Det. Mack "Mac" Taylor Actor Sela Ward Jo Danville Actor Carmine Giovinazzo Det. Danny Messer Actor Hill Harper Dr. Sheldon Hawkes Actor Eddie Cahill Det. Donald Flack, Jr. Actor Anna Belknap Det. Lindsay Monroe Messer Actor A.J. Buckley Adam Ross Actor Robert Joy Dr. Sid Hammerback Actor Glenn Taranto James Sheehan Guest Star Katie Boggs Sarah Nelson Guest Star Brett Tucker Theodore Westwick Guest Star Lawrence Monoson Rudy Aronika Guest Star Sean Maguire Alex Brodevesky Guest Star Jane McLean Dr. Morgan Jefferson Guest Star Andrew Keegan Simon Guest Star Karina D'Bautista Lab Tech Guest Star Jerry Bruckheimer Executive Producer Carol Mendelsohn Executive Producer Ann Donahue Executive Producer Anthony Zuiker Executive Producer Danny Cannon Executive Producer Andrew Lipsitz Executive Producer John Dove Writer Pam Veasey Writer Duane Clark Director