Episode 1
Aired Apr 20, 2026
A Mother's Lump
Angela has a big, melon-sized growth on the back of her neck that she fears can ruin her daughter's wedding; Loretta is terrified that her painful can get in the way of making her movie.
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Episode 2
Aired Apr 27, 2026
Gone in CYST-Y Seconds
John is a sweet guy trying to get over his bumpy past; Tami has yellow deposits on her eyelids that make it impossible for her to feel beautiful; Dr. Farhang helps Dr. Lee with a terrified patient, Lili, who has a lump on the back of her arm.
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Episode 3
Aired May 4, 2026
A Cheeky Bump
Dave has 17 huge, painful head bumps; Melissa recently moved to a new town but her mysterious red, scaly lesions cover her legs; Glamorous dermatologist Dr. Shearer Seymour shadows Dr. Lee as they attempt to remove a pointy cyst from Sam's cheek.
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Episode 3
Aired Apr 20, 2026
Second Chances
The stress of dealing with dermatological issues can go beyond skin deep. This episode revisits four memorable cases where Dr. Sandra Lee aims to improve the mental health and quality of life of her patients and provide them with a new lease on life.
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Episode 4
Aired May 11, 2026
The Danger Triangle
Jeana has huge, spherical growths dangling from her ears; Alondra owns a flower shop but her painful, hydrangea-sized back bump prevents her from helping customers; Dr. Lee shows Dr. Lyndsay how to avoid the Danger Triangle.
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Episode 4
Aired Apr 20, 2026
Braving the Pop
The journey to addressing certain skin ailments is one to be tread lightly, especially for those overcome with anxiety. This special explores four patients who had to confront their fears surrounding treatment.
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Episode 5
Aired May 18, 2026
A Bronx Bump
Tana deals with an abusive past, and a forehead bump; Ernestine, a die-hard Yankees fan, has a huge, misshapen growth on her back; Dr. Lee teaches eager dermatology intern Dr. Hannah Tolson how to remove Foday's mystery bumps named Mama and Baby.
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Episode 6
Aired May 25, 2026
It's All in the Hips
John is bound to a wheelchair and ready to give up after his legs have become too swollen, painful, and smelly; Chad's painful, giant hip growth; Dr. Farhang helps Dr. Lee with John's large cheek growth.
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Episode 7
Aired Jun 1, 2026
Backcountry Bump
Veronica has a huge mango-sized growth on her back; Thomas has a deep passion for cosplay but is too embarrassed to dress up due to the large bump on their head; Dr. Lyndsey returns to help Dr. Lee shape former golf pro Ken's lumpy, bumpy nose.
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Episode 8
Aired Jun 8, 2026
A Pain In the Bump
Candace is a singer and doula whose huge face bump is stealing her youth; Christian has ignored the terrifying growth hanging off his tush; Otito worries that the extreme, thickened skin on her hands and feet will end her dental career.
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Episode 9
Aired Jun 15, 2026
Life Lesions
Dr. Tolson learns how to help Dr. Lee treat Mary Beth's bumpy, mysteriously-changing face lesions; Dr. Ortiz steps in to help Kathy, who has thousands of red dots on her body that keep her from confidently wearing a bathing suit.
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Episode 10
Aired Jun 22, 2026
Retraining the Brain
Dr. Lee, occupational therapist, arrives to help re-train her body post-stroke; Justin arrives with a body-covering, angry rash; Dr. Lee can only observe as Dr. Farhang attempts to remove AJ's huge forehead bump.
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Episode 11
Aired Jun 29, 2026
Two Derms Are Better Than One
As Dr. Lee continues to recover from her stroke, she calls in reinforcements from Montana, her old dermatology residency pal, Dr. Kristen Townley.
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Episode 12
Aired Jul 6, 2026
Painless Lee & Fearless Townley
As she continues to recover from her stroke, Dr. Lee again enlists her Montana friend Dr. Kristen Townley to remove Paul's concerning windpipe bump; the doctors also try to help Kellie, who has a large, possibly vascular lump on the side of her head.
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Episode 13
Aired Jul 13, 2026
Cleared for Surgery!
Dr. Lee is cleared to perform surgery; as she continues to rehab, she and Montana surgeon Dr. Kristen Townley work together to help Brandi, whose huge back bump is hurting her mobility and her relationship with her new boyfriend Phillip.
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Episode 14
Airs Jul 20
A Nosey Nuisance
Brittany's home and career life are in shambles since her nose and cheeks erupted with bright red, oozing bumps. Dr. Sheila Farhang joins Dr. Lee for a lesson on how to remove John's painful, inflamed cysts.
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Episode 15
Airs Jul 27
Hand Me That Scalpel!
Dr. Lee is ready to take the lead on her first surgery since her stroke, with Dr. Townley now assisting. Quentin has a cantaloupe-sized bump on his tricep that is ruining his mechanic career and making his girlfriend miserable.
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Episode 16
Airs Aug 3
Hiding Behind a Wig
Craig fears the massive growth on his neck could prevent him from helping his sick mother. Gwen is covered in dry, itchy patches that are causing hair loss and devastating her confidence.
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Episode 17
Airs Aug 10
Pop Star
Sevyn Streeter visits Dr. Lee with her friend Rose, who is concerned an unsightly shoulder lump is ruining her modeling career. Jamie is a family man who fears his young daughter is growing something that matches his angry, huge neck growth.
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Episode 18
Airs Aug 17
Looking for Love
Charming Justin feels the thousands of bumps covering his face and body ruin his chance to find love. Reclusive Gene's girlfriend is frustrated that he will only leave the house to watch trains due to the gigantic lump on his head.
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Episode 19
Airs Aug 24
Dr. Sandra Lee, also known as Dr. Pimple Popper, is ready to take her practice to the next level. Dr. Lee will be providing intimate self-shot footage of her life outside the office.
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Episode 20
Airs Aug 31
'Til Next Time, Partner
Dr. Lee expresses appreciation to her friend Dr. Kristen Townley. Matline has a passion for horseback riding, but a painful bump on her back could end her time in the saddle. Steph Tolev is concerned about a head bump.
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