Emily Watson Valya Harkonnen Actor Olivia Williams Tula Harkonnen Actor Travis Fimmel Desmond Hart Actor Jodhi May Empress Natalya Actor Mark Strong Emperor Javicco Corrino Actor Sarah-Sofie Boussnina Princess Ynez Actor Josh Heuston Constantine Corrino Actor Chloe Lea Lila Actor Jade Anouka Sister Theodosia Actor Edward Davis Harrow Harkonnen Actor Aoife Hinds Sister Emeline Actor Chris Mason Keiran Atreides Actor Shalom Brune-Franklin Mikaela Actor Jihae Reverend Mother Kasha Jinjo Actor Tabu Sister Francesca Actor Charithra Chandran Young Francesca Actor Jessica Barden Actor Emma Canning Actor Yerin Ha Actor