Jonny Lee Miller Sherlock Holmes Actor Lucy Liu Dr. Joan Watson Actor Aidan Quinn Capt. Tobias "Toby" Gregson Actor Manny Perez Detective Javier Abreu Guest Star Dallas Roberts Dr. Richard Mantlo Guest Star Craig Walker Peter Saldua Guest Star Jonathan Walker Harrison Polk Guest Star Annika Boras Amy Damper Guest Star Ward Horton Soap Opera Actor Guest Star Randal Turner Male Opera Singer Guest Star Melissa Zapin Female Opera Singer Guest Star Kristen Bush Eileen Renfro Guest Star Michael Nathanson Infomercial Narrator Guest Star Sherry H. Arell Shushing Lady Guest Star Robert Doherty Executive Producer, Writer Sarah Timberman Executive Producer Carl Beverly Executive Producer Michael Cuesta Executive Producer, Director