Jonny Lee Miller Sherlock Holmes Actor Lucy Liu Dr. Joan Watson Actor Aidan Quinn Capt. Tobias "Toby" Gregson Actor Jon Michael Hill Detective Marcus Bell Actor Natalie Dormer Irene Adler Guest Star Erik Jensen Isaac Proctor Guest Star Lucas Caleb Rooney Duane Proctor Guest Star John Bedford Lloyd Lieutenant Guest Star Christopher McCann Dr. Del Santo Guest Star Frank Deal Detective Mike Muldoon Guest Star Robert Doherty Executive Producer, Writer Sarah Timberman Executive Producer Carl Beverly Executive Producer Michael Cuesta Executive Producer Craig Sweeny Writer Seith Mann Director