Jonny Lee Miller Sherlock Holmes Actor Lucy Liu Joan Watson Actor Aidan Quinn Captain Thomas Gregson Actor Jon Michael Hill Detective Marcus Bell Actor Susan Pourfar Emily Hankins Guest Star Christian Campbell Ezra Kleinfelter Guest Star Ronald Guttman Elliot Honeycutt Guest Star Laura Osnes Celia Carroll Guest Star Peter McRobbie Milton Van Kirk Guest Star Adeel Ahmed Marcus Guest Star Joe Cassidy Agent 1 Guest Star Scott Whitehurst Agent 2 Guest Star Juan Carlos Infante CSU Tech Guest Star Anthony Fazio Delivery Man Guest Star Chester Jones III Bike Cop Guest Star Robert Doherty Executive Producer Carl Beverly Executive Producer Sarah Timberman Executive Producer Craig Sweeny Executive Producer, Writer Michael Pressman Director