Jonny Lee Miller Sherlock Holmes Actor Lucy Liu Joan Watson Actor Aidan Quinn Captain Thomas Gregson Actor Jon Michael Hill Detective Marcus Bell Actor Alicia Witt Dana powell Guest Star Michael Cumpsty Arlen Schrader Guest Star Maria Dizzia Penny Guest Star Jason Pendergraft Freddy Duncan Guest Star Peter Jay Fernandez Samuel Cardenas Guest Star Julia Murney Gayle Wolper Guest Star Anastasia Barzee Erin Chatworth Guest Star Fred Arsenault Building Manager Guest Star Craig Wroe Dana's Lawyer Guest Star Bob Ari Jeweler Guest Star Cathleen Trigg Reporter Guest Star Mario Basquez News Anchor Guest Star Moti Margolin Henry Wilseck Guest Star Robert Doherty Executive Producer Carl Beverly Executive Producer Sarah Timberman Executive Producer Craig Sweeny Executive Producer Bob Goodman Writer Jerry Levine Director