Jonny Lee Miller Sherlock Holmes Actor Lucy Liu Joan Watson Actor Aidan Quinn Captain Thomas Gregson Actor Jon Michael Hill Detective Marcus Bell Actor John Noble Mr. Morland Holmes Actor Susan Pourfar Emily Hankins Guest Star Gabriel Olds Dr. Nate Campbell Guest Star Robert Manning Jr. Dr. Branford Fisher Guest Star Jenn Colella Blonde Group Wife Guest Star Stephanie Janssen Trish Guest Star Donald Sage Mackay Ben Guest Star Gene Gillette Group Husband with Plaid Shirt Guest Star Carolyn McCormick Denise Davis Guest Star Monique Curnen Detective Gina Cortes Guest Star Quincy Tyler Bernstine Tamara Guest Star Sanjit De Silva Dr. Amrit Guest Star Jacqueline Antaramian Russof Guest Star John Ellison Conlee Kirk Abramovitch Guest Star Heidi Armbruster Sadie Abramovitch Guest Star Mark Jacoby Lawyer Guest Star Mairin Lee Abby Campbell Guest Star Robert Doherty Executive Producer Carl Beverly Executive Producer Sarah Timberman Executive Producer John Polson Executive Producer Jason Tracey Executive Producer Robert Hewitt Wolfe Writer Michael Pressman Director