David Angell Creator, Executive Producer Peter Casey Creator, Executive Producer David Lee Creator, Executive Producer Kelsey Grammer Dr. Frasier Crane Actor, Executive Producer John Mahoney Martin Crane Actor Jane Leeves Daphne Moon Actor David Hyde Pierce Dr. Niles Crane Actor Peri Gilpin Roz Doyle Actor Patti LuPone Aunt Zora Crane Guest Star Joseph Will Nikos Crane Guest Star John Mahon Uncle Walt Crane Guest Star Valerie Dillman Mary Ann Guest Star James Gleason Ed Guest Star Lori Harmon Cousin Yvonne Guest Star Christopher Lloyd Executive Producer Jeff Melman Director David Lloyd Writer