Kelsey Grammer Dr. Frasier Crane Actor, Executive Producer John Mahoney Martin Crane Actor Jane Leeves Daphne Moon Actor David Hyde Pierce Dr. Niles Crane Actor Peri Gilpin Roz Doyle Actor Gigi Rice Regan Shaw Guest Star Katie Finneran Poppy Guest Star David Angell Executive Producer Peter Casey Executive Producer David Lee Executive Producer Christopher Lloyd Executive Producer, Writer Joe Keenan Executive Producer Katy Garretson Director