Kelsey Grammer Dr. Frasier Crane Actor, Executive Producer, Director David Hyde Pierce Dr. Niles Crane Actor John Mahoney Martin Crane Actor Jane Leeves Daphne Moon Actor Peri Gilpin Roz Doyle Actor Jean Smart Lana Gardner Guest Star Rene Auberjonois Professor William Tewksbury Guest Star Saul Rubinek Guest Star Kim Coles Dr. Mary Guest Star Dave Allen Randy Guest Star Patricia Clarkson Claire French Guest Star Jane Adams Guest Star Patrick Macnee Cecil Hedley Guest Star Tom McGowan Kenny Daly Guest Star Brian Klugman Kirby Guest Star Mary-Joan Negro Joanne Guest Star Elizabeth Alley Margaret Guest Star Edward Hibbert Gil Chesterton Guest Star Michael Rothhaar Party Guest Guest Star Karl T. Wright Producer Guest Star David Angell Executive Producer Peter Casey Executive Producer David Lee Executive Producer, Director Mark Reisman Executive Producer, Writer Dan O'Shannon Executive Producer, Writer Pamela Fryman Director Sheldon Epps Director Jon Sherman Writer Sam Johnson Writer Rob Hanning Writer Bob Daily Writer Lori Kirkland Baker Writer Eric Zicklin Writer Saladin K. Patterson Writer Chris Marcil Writer