Sophia Bush Dr. Sam Griffith Actor Jason Isaacs Dr. Rob "Griff" Griffith Actor Skye P. Marshall Dr. Lex Trulie Actor Michael Stahl-David Dr. Caleb Tucker Actor Davi Santos Dr. Joey Costa Actor Omar Maskati Dr. Isan M. Shah Actor Wendy Crewson Vivian Katz Actor Edwin Hodge Malcolm A. Kingsley Actor Marium Carvell Nurse Donna Williams Guest Star Evan Parke Byron Kingsley Guest Star Sabryn Rock Roman's Mom Guest Star Milton Barnes Roman's Dad Guest Star Keira Loughran Dr. Danielle Hamamura Guest Star David D'Lancy Wilson Ted Morris Guest Star Natalia Gracious Crash Nurse Guest Star Seema Doad Scrub Nurse Jodie Guest Star Jahzara Rankine Ellie Guest Star Katie Wech Executive Producer, Writer Jennie Snyder Urman Executive Producer Joanna Klein Executive Producer Frank Siracusa Executive Producer John Weber Executive Producer Randy Zisk Director