Blake Lively Serena van der Woodsen Actor Leighton Meester Blair Waldorf Actor Chace Crawford Nate Archibald Actor Penn Badgley Dan Humphrey Actor Taylor Momsen Jenny Humphrey Actor Ed Westwick Chuck Bass Actor Kelly Rutherford Lily van der Woodsen Actor Matthew Settle Rufus Humphrey Actor Patrick Heusinger Lord Marcus Beaton Guest Star Jessica Szohr Vanessa Abrams Guest Star Mädchen Amick Duchess Catherine Beaton Guest Star Margaret Colin Eleanor Waldorf Guest Star Alex Carl Laurel's Assistant Actor Josh Schwartz Executive Producer Stephanie Savage Executive Producer Janice Cooke Director John Stephens Writer