Ellen Pompeo Dr. Meredith Grey Actor Patrick Dempsey Dr. Derek Shepherd Actor James Pickens Jr. Dr. Richard Webber Actor T.R. Knight Dr. George O'Malley Actor Sandra Oh Dr. Cristina Yang Actor Katherine Heigl Dr. Izzie Stevens Actor Chandra Wilson Dr. Miranda Bailey Actor Isaiah Washington Dr. Preston Burke Actor Justin Chambers Dr. Alex Karev Actor Kate Walsh Dr. Addison Montgomery Actor Kate Burton Guest Star Don McManus Guest Star Lee Garlington Guest Star Tsai Chin Guest Star Thomas Ian Nicholas Guest Star Katherine LaNasa Guest Star Steven W. Bailey Guest Star Moe Irvin Guest Star Kathleen M. Darcy Guest Star Noelle McCutchen Guest Star Linda Eve Miller Guest Star Dan Wilson Guest Star Shonda Rhimes Executive Producer Mark Gordon Executive Producer Betsy Beers Executive Producer James D. Parriott Executive Producer Zoanne Clack Writer Wendey Stanzler Director