Ellen Pompeo Dr. Meredith Grey Actor Patrick Dempsey Dr. Derek Shepherd Actor James Pickens Jr. Dr. Richard Webber Actor T.R. Knight Dr. George O'Malley Actor Sandra Oh Dr. Cristina Yang Actor Katherine Heigl Dr. Izzie Stevens Actor Chandra Wilson Dr. Miranda Bailey Actor Isaiah Washington Dr. Preston Burke Actor Justin Chambers Dr. Alex Karev Actor Kate Walsh Dr. Addison Montgomery Actor Rosanna Arquette Guest Star Timothy Bottoms Guest Star Margaret Welsh Guest Star Pat Healy Guest Star Curtis Armstrong Guest Star Sarah Utterback Guest Star Patricia Bethune Guest Star Monica Garcia Guest Star Elaine Kao Guest Star Brooke Blanchard Guest Star Amie Donegan Guest Star Shonda Rhimes Executive Producer Mark Gordon Executive Producer Betsy Beers Executive Producer James D. Parriott Executive Producer Mark Wilding Writer Daniel Minahan Director