Ellen Pompeo Dr. Meredith Grey Actor Patrick Dempsey Dr. Derek Shepherd Actor James Pickens Jr. Dr. Richard Webber Actor T.R. Knight Dr. George O'Malley Actor Sandra Oh Dr. Cristina Yang Actor Katherine Heigl Dr. Izzie Stevens Actor Chandra Wilson Dr. Miranda Bailey Actor Isaiah Washington Dr. Preston Burke Actor Justin Chambers Dr. Alex Karev Actor Kate Walsh Dr. Addison Montgomery Actor Sara Ramirez Guest Star Mary Kay Place Guest Star Anjul Nigam Guest Star Jeffrey Dean Morgan Guest Star Omar Metwally Guest Star Michaela Watkins Guest Star Annie Morgan Guest Star Kathleen M. Darcy Guest Star Brooke Blanchard Guest Star Wayne Lopez Guest Star Kerry Carney Guest Star Rob Narita Guest Star Kate Anthony Guest Star Shenita Moore Guest Star Keeshan Giles Guest Star Linda Klein Guest Star Shonda Rhimes Executive Producer Mark Gordon Executive Producer Betsy Beers Executive Producer James D. Parriott Executive Producer Tricia Brock Director Jim Parriott Writer