Ellen Pompeo Dr. Meredith Grey Actor Patrick Dempsey Dr. Derek Shepherd Actor Sandra Oh Dr. Cristina Yang Actor Isaiah Washington Dr. Preston Burke Actor Katherine Heigl Dr. Izzie Stevens Actor Justin Chambers Dr. Alex Karev Actor T.R. Knight Dr. George O'Malley Actor Chandra Wilson Dr. Miranda Bailey Actor James Pickens Jr. Dr. Richard Webber Actor Kate Walsh Dr. Addison Montgomery Actor Sara Ramirez Dr. Callie Torres Actor Eric Dane Dr. Mark Sloan Actor Elizabeth Reaser Guest Star Kate Burton Guest Star George Dzundza Guest Star Jeff Perry Guest Star Steven W. Bailey Guest Star Moe Irvin Guest Star Kate Anthony Guest Star Mare Winningham Guest Star Shonda Rhimes Executive Producer, Writer Mark Gordon Executive Producer Betsy Beers Executive Producer James D. Parriott Executive Producer Krista Vernoff Writer Stacy McKee Writer Debora Cahn Writer Allan Heinberg Writer Tony Phelan Writer Rob Corn Director Michael Grossman Director Jeff Melman Director Daniel Minahan Director Julie Anne Robinson Director Christopher Misiano Director Greg Yaitanes Director Adam Arkin Director Harry Werksman Writer Joan Rater Writer