Ellen Pompeo Dr. Meredith Grey Actor Patrick Dempsey Dr. Derek Shepherd Actor Sandra Oh Dr. Cristina Yang Actor Isaiah Washington Dr. Preston Burke Actor Katherine Heigl Dr. Izzie Stevens Actor Justin Chambers Dr. Alex Karev Actor T.R. Knight Dr. George O'Malley Actor Chandra Wilson Dr. Miranda Bailey Actor James Pickens Jr. Dr. Richard Webber Actor Kate Walsh Dr. Addison Montgomery Actor Sara Ramirez Dr. Callie Torres Actor Eric Dane Dr. Mark Sloan Actor Kate Burton Guest Star George Dzundza Guest Star Myndy Crist Guest Star Greg Pitts Guest Star Tim Griffin Guest Star Matt Winston Guest Star Paul Cassell Guest Star Annie Campbell Guest Star Steven W. Bailey Guest Star Ray Ford Guest Star Brooke Bryan Guest Star Martin Yu Guest Star Shonda Rhimes Executive Producer Mark Gordon Executive Producer Betsy Beers Executive Producer James D. Parriott Executive Producer Gabrielle G. Stanton Writer Harry Werksman Writer Jeff Melman Director