Ellen Pompeo Dr. Meredith Grey Actor Patrick Dempsey Dr. Derek Shepherd Actor Sandra Oh Dr. Cristina Yang Actor Isaiah Washington Dr. Preston Burke Actor Katherine Heigl Dr. Izzie Stevens Actor Justin Chambers Dr. Alex Karev Actor T.R. Knight Dr. George O'Malley Actor Chandra Wilson Dr. Miranda Bailey Actor James Pickens Jr. Dr. Richard Webber Actor Kate Walsh Dr. Addison Montgomery Actor Sara Ramirez Dr. Callie Torres Actor Eric Dane Dr. Mark Sloan Actor Loretta Devine Guest Star Elizabeth Reaser Guest Star Jeff Perry Guest Star Steven W. Bailey Guest Star Aasha Davis Guest Star Kevin Rankin Guest Star Brian Tee Guest Star Jack Yang Guest Star Derek Phillips Guest Star Mandy Siegfried Guest Star Tim Chiou Guest Star Nicole Rubio Guest Star Michelle N. Carter Guest Star Shonda Rhimes Executive Producer Mark Gordon Executive Producer Betsy Beers Executive Producer James D. Parriott Executive Producer Allan Heinberg Writer Christopher Misiano Director