Ellen Pompeo Dr. Meredith Grey Actor Patrick Dempsey Dr. Derek Shepherd Actor Sandra Oh Dr. Cristina Yang Actor Katherine Heigl Dr. Izzie Stevens Actor Justin Chambers Dr. Alex Karev Actor T.R. Knight Dr. George O'Malley Actor Chandra Wilson Dr. Miranda Bailey Actor James Pickens Jr. Dr. Richard Webber Actor Sara Ramirez Dr. Callie Torres Actor Eric Dane Dr. Mark Sloan Actor Chyler Leigh Dr. Lexie Grey Actor Brooke Smith Dr. Erica Hahn Actor Seth Green Guest Star Elizabeth Reaser Guest Star Gale Harold Guest Star Cress Williams Guest Star Lauren Stamile Guest Star John Billingsley Guest Star Alison La Placa Guest Star Kimberly Huie Guest Star Theo Rossi Guest Star Ray Ford Guest Star Shanelle Workman Guest Star Mark Saul Guest Star Martin Yu Guest Star Kate Anthony Guest Star Crystal Kwon Guest Star Patricia Bethune Guest Star Moe Irvin Guest Star Emma Prescott Guest Star Suzi Hofrichter Guest Star Parker Goris Guest Star Kate Mines Guest Star Shonda Rhimes Executive Producer, Writer Mark Gordon Executive Producer Betsy Beers Executive Producer James D. Parriott Executive Producer Krista Vernoff Writer Jessica Yu Director