Ellen Pompeo Dr. Meredith Grey Actor Patrick Dempsey Dr. Derek Shepherd Actor Sandra Oh Dr. Cristina Yang Actor Katherine Heigl Dr. Izzie Stevens Actor Justin Chambers Dr. Alex Karev Actor T.R. Knight Dr. George O'Malley Actor Chandra Wilson Dr. Miranda Bailey Actor James Pickens Jr. Dr. Richard Webber Actor Sara Ramirez Dr. Callie Torres Actor Eric Dane Dr. Mark Sloan Actor Chyler Leigh Dr. Lexie Grey Actor Brooke Smith Dr. Erica Hahn Actor Kevin McKidd Owen Hunt Guest Star Mariette Hartley Guest Star Lauren Stamile Guest Star Cliff DeYoung Guest Star John Getz Guest Star Bernadette Peters Guest Star Kathy Baker Guest Star Mark Saul Guest Star Amrapali Ambegaokar Guest Star Shonda Rhimes Executive Producer Mark Gordon Executive Producer Betsy Beers Executive Producer James D. Parriott Executive Producer