Ellen Pompeo Dr. Meredith Grey Actor Patrick Dempsey Dr. Derek Shepherd Actor Sandra Oh Dr. Cristina Yang Actor Katherine Heigl Dr. Izzie Stevens Actor Justin Chambers Dr. Alex Karev Actor T.R. Knight Dr. George O'Malley Actor Chandra Wilson Dr. Miranda Bailey Actor James Pickens Jr. Dr. Richard Webber Actor Sara Ramirez Dr. Callie Torres Actor Eric Dane Dr. Mark Sloan Actor Chyler Leigh Dr. Lexie Grey Actor Kevin McKidd Owen Hunt Actor Jeffrey Dean Morgan Guest Star Tyne Daly Guest Star Melissa George Guest Star Eric Stoltz Guest Star Jessica Capshaw Guest Star Samantha Mathis Guest Star Jason Kravits Guest Star Ernie Grunwald Guest Star Brandon Scott Guest Star Aaron Refvem Guest Star Gloria Garayua Guest Star Mark Saul Guest Star Molly Kidder Guest Star Candice Afia Guest Star Shonda Rhimes Executive Producer Mark Gordon Executive Producer Betsy Beers Executive Producer James D. Parriott Executive Producer Jenna Bans Writer Jeannot Szwarc Director