Rachel Bilson Dr. Zoe Hart Actor Jaime King Lemon Breeland Actor Wilson Bethel Wade Kinsella Actor Cress Williams Lavon Hayes Actor Scott Porter George Tucker Actor Tim Matheson Dr. Brick Breeland Actor Kaitlyn Black AnnaBeth Nass Actor Laura Bell Bundy Shelby Sinclair Guest Star McKaley Miller Rose Hattenbarger Guest Star Brandi Burkhardt Crickett Watts Guest Star Ross Philips Tom Long Guest Star Mallory Moye Wanda Long Guest Star Erica Piccininni Jaysene Charles Guest Star Claudia Lee Magnolia Breeland Guest Star Matt Lowe Meatball Guest Star Meredith Monroe Alice Kincaid Guest Star Talitha Eliana Bateman Scarlett Kincaid Guest Star Carla Renata Susie Guest Star Leila Gerstein Executive Producer Josh Schwartz Executive Producer Stephanie Savage Executive Producer Len Goldstein Executive Producer Jason Ensler Executive Producer Ricardo Méndez Matta Director Amy Roy Writer