Hugh Laurie Dr. Gregory House Actor Robert Sean Leonard Dr. James Wilson Actor Omar Epps Dr. Eric Foreman Actor Jesse Spencer Dr. Robert Chase Actor Peter Jacobson Dr. Chris Taub Actor Odette Annable Dr. Jessica Adams Actor Charlyne Yi Dr. Chi Park Actor Jamie Bamber Bob Harris Guest Star Carlie Casey Cindy Guest Star Heather Stephens Denise Harris Guest Star Blake Bertrand David Harris Guest Star Natalie Dye Sally Harris Guest Star E.E. Bell Mayor Collins Guest Star Erika L. Holmes Prostitute Guest Star Ed Zajac Client Guest Star Vincent Angelo Manny Guest Star Bobbin Bergstrom Nurse Guest Star Paul Attanasio Executive Producer Katie Jacobs Executive Producer David Shore Executive Producer Bryan Singer Executive Producer Kate Woods Director John C. Kelley Writer