Damon Wayans Roger Murtaugh Actor Clayne Crawford Martin Riggs Actor Jordana Brewster Dr. Maureen "Mo" Cahill Actor Kevin Rahm Captain Brooks Avery Actor Keesha Sharp Trish Murtaugh Actor Johnathan Fernandez Scorsese Actor Dante Brown Roger Murtaugh Jr. Actor Chandler Kinney Riana Murtaugh Actor Michelle Mitchenor Sonya Bailey Guest Star Hilarie Burton Agent Karen Palmer Guest Star Tony Plana Ronnie Delgado Guest Star Matt Passmore Gideon Lyon Guest Star Daniella Alonso Maria Navar Guest Star Ned Vaughn Agent Chappel Guest Star Matt Miller Executive Producer McG Executive Producer Dan Lin Executive Producer Jennifer Gwartz Executive Producer