Damon Wayans Roger Murtaugh Actor Clayne Crawford Martin Riggs Actor Kevin Rahm Captain Brooks Avery Actor Jordana Brewster Dr. Maureen "Mo" Cahill Actor Keesha Sharp Trish Murtaugh Actor Johnathan Fernandez Scorsese Actor Michelle Mitchenor Detective Bailey Actor Dante Brown Roger Murtaugh Jr. Actor Chandler Kinney Riana Murtaugh Actor Eric Ladin Gordon Barnes Guest Star Katie Walder Denise Barnes Guest Star Manuel Uriza Raul Mendez Guest Star Beth Littleford Internal Affairs Agent Guest Star Monty Jenkins George Sharperson Guest Star Danny Mora Tito Flores Guest Star Matt Miller Executive Producer McG Executive Producer Dan Lin Executive Producer Jennifer Gwartz Executive Producer