Damon Wayans Roger Murtaugh Actor Clayne Crawford Martin Riggs Actor, Director Kevin Rahm Captain Brooks Avery Actor Jordana Brewster Dr. Maureen "Mo" Cahill Actor Keesha Sharp Trish Murtaugh Actor Johnathan Fernandez Scorsese Actor Michelle Mitchenor Detective Bailey Actor Dante Brown Roger Murtaugh Jr. Actor Chandler Kinney Riana Murtaugh Actor Floriana Lima Miranda Riggs Guest Star Thomas Lennon Leo Getz Guest Star Tony Plana Ronnie Delgado Guest Star Tim Kang Mike Serrano Guest Star Michael Reilly Burke Councilman Sean O'Brien Guest Star C.S. Lee Gene Nakahara Guest Star Bill Kalmenson Chief Jon Winslow Guest Star Edward Singletary Dan Reiser Guest Star Karissa Vacker Kate Guest Star George Sharperson Monty Guest Star Buckley Sampson Nurse 1 Guest Star Marcus Brown Tiny Guest Star Brandee Evans Nurse 2 Guest Star Matt Miller Executive Producer McG Executive Producer Dan Lin Executive Producer Jennifer Gwartz Executive Producer Steve Boyum Director Omar Madha Director Eric Laneuville Director Salli Richardson-Whitfield Director Maja Vrvilo Director John Behring Director Larry Teng Director Silver Tree Director Nick Copus Director