Damon Wayans Roger Murtaugh Actor Clayne Crawford Martin Riggs Actor, Director Kevin Rahm Captain Brooks Avery Actor Jordana Brewster Dr. Maureen "Mo" Cahill Actor Keesha Sharp Trish Murtaugh Actor Johnathan Fernandez Scorsese Actor Michelle Mitchenor Detective Bailey Actor Dante Brown Roger Murtaugh Jr. Actor Chandler Kinney Riana Murtaugh Actor Michelle Hurd Chief Gina Santos Guest Star Andrew Creer Detective Bowman Guest Star Rex Linn Nathan Riggs Guest Star Luis Jose Lopez Stanley Oliver Guest Star Matt Malloy Dr. Samuels Guest Star Kelly Coffield Park Peggy Guest Star Craig Gellis Carl Edwards Guest Star George Emil Ketsios Alan Guest Star Matt DiBenedetto Guest Star Matt Miller Executive Producer McG Executive Producer Dan Lin Executive Producer Jennifer Gwartz Executive Producer Steve Boyum Director Omar Madha Director Eric Laneuville Director Salli Richardson-Whitfield Director Maja Vrvilo Director John Behring Director Larry Teng Director Silver Tree Director Nick Copus Director