Damon Wayans Roger Murtaugh Actor Seann William Scott Wesley Cole Actor Kevin Rahm Captain Brooks Avery Actor Jordana Brewster Dr. Maureen "Mo" Cahill Actor Keesha Sharp Trish Murtaugh Actor Johnathan Fernandez Scorsese Actor Michelle Mitchenor Detective Bailey Actor Dante Brown Roger Murtaugh Jr. Actor Chandler Kinney Riana Murtaugh Actor Andrew Patrick Ralston Jim McNeile Guest Star Michelle Hurd Gina Santos Guest Star Maggie Lawson Natalie Guest Star André Eriksen Zovra Guest Star Peter Coventry Smith Garrett Guest Star Marlon Young George Guest Star Shay Rudolph Maya Guest Star Matt Miller Executive Producer McG Executive Producer Dan Lin Executive Producer Jennifer Gwartz Executive Producer