Clark Gregg Agent Phil Coulson Actor Ming-Na Wen Agent Melinda May Actor Chloe Bennet Daisy Johnson Actor Iain De Caestecker Agent Leo Fitz Actor Elizabeth Henstridge Agent Jemma Simmons Actor Henry Simmons Agent Alphonso "Mack" MacKenzie Actor John Hannah Holden Radcliffe Actor Brett Dalton Grant Ward Guest Star Mallory Jansen Madame Hydra, Aida Guest Star Jordan Rivera Hope Mackenzie Guest Star David Weiss Serious Man Guest Star Patrick Cavanaugh Burrows Guest Star Zach McGowan The Superior Guest Star David O'Hara Alistair Guest Star Ben Cain Hydra Agent Guest Star Andy Comeau Hydra Doctor Guest Star Kavita Patil Mrs. Lee Guest Star Joss Whedon Executive Producer Jed Whedon Executive Producer Maurissa Tancharoen Executive Producer Jeffrey Bell Executive Producer Jeph Loeb Executive Producer James Oliver Writer Sharla Oliver Writer Billy Gierhart Director