Michael Sheen William Masters Actor, Producer Lizzy Caplan Virginia Johnson Actor Caitlin FitzGerald Libby Masters Actor Annaleigh Ashford Betty DiMello Actor Teddy Sears Guest Star Aaron Abrams Guest Star Lisa Banes Guest Star Steve Bannos Guest Star Kevin Christy Guest Star Nick Clifford Guest Star Kelli O'Hara Guest Star Rick Peters Guest Star Stephen Root Guest Star Romy Rosemont Guest Star Charles Shaughnessy Guest Star Michelle Ashford Executive Producer Sarah Timberman Executive Producer Carl Beverly Executive Producer Judith Verno Executive Producer Amy Lippman Executive Producer Julie Anne Robinson Director Esta Spalding Writer