The tenth season of Murder, She Wrote begins as Jessica Fletcher (Angela Lansbury) travels to Hong Kong, where she attends a banquet honoring a high-profile American businessman. With Jessica in attendance, a murder is a foregone conclusion--and sure enough, the businessman is poisoned to death. Coul this be tied in with the dead man's efforts to merge with the head of a controversial Chinese manufacturing firm? The answer may be within a hundred-year-old egg that Jessica holds in her well-manicured hand.

The 200th episode of Murder, She Wrote finds Jessica (Angela Lansbury) supporting an effort to preserve a New York brownstone where Ernest Hemingway once wrote a novel. At the center of the conflict is a feud between Jessica's editor and a powerful land developer. Murder enters the scene when the brother of the man who opposes destroying the building is killed. And it is a bad kill. And nobody is dreaming about the lions.

A mysterious gentleman named Lawrence Baker (David Birney) moves into Cabot Cove and takes possession of a Victorian mansion that is regarded as a local landmark. Baker's curious behavior causes rumors to fly that there is something supernatural, even vampiric about him. And then, Baker is found dead...with a wooden stake through his heart. Jessica (Angela Lansbury) of course wants to find out what really happened--after all, detective work is in her bloooood!

Unscrupulous media mogul Harrison M. Kane (Alan Thicke) is murdered. The main suspect is writer Dean Richards (Scott Valentine), a freelance contributor to one of Kane's rivals--and in whose sauna bath Kane's body was found. But as Jessica investigates the case, it becomes apparent that there's an elusive "phantom killer" at large. Perhaps it is significant that at least one of the episode's main characters goes under two different names (Only perhaps?)

Jessica (Angela Lansbury) agrees to write a mystery scenario for a new interactive video game created by an eccentric electronics genius. While sampling the game's "virtual reality" mode, Jessica witnesses what appears to be a murder. Sure enough, the game's inventor has been killed is "real" reality--and the suspect list nearly sends Jessica into overload!

In 1944, Angela Lansbury and Mickey Rooney both appeared in the classic racetrack film National Velvet. The two veterans are reunited in this story, which appropriately enough revolves around a thoroughbred horse, and two families who have staked everything in an upcoming race. When her old friend, horse trainer Matt Cleveland (Rooney), is murdered, Jessica (Lansbury) hits the trail of clues and collars the killer in the home stretch.

Making her annual pilgrimage to Ireland, Jessica (Angela Lansbury) is determined to catch up with the sightseeing that has so often been interrupted in the past by murder. Alas, it isn't long before our heroine is involved in another homicide case. This time around, the eldest son (Gordon Currie) of Jessica's widowed friend Fiona Griffith (Fionnula Flanagan) is accused of killing the American cousin (Andrew Robinson) who had planned to horn in on the family business.

Jessica (Angela Lansbury) returns home from New York when she finds out that her accountant Samuel Bennett (Wings Hauser) hasn't been paying her bills in Cabot Cove. It turns out that Bennett is deeply in debt to a local illicict gambling casino. Soon after, a crooked deputy (Matthew Flint) is killed--and among the suspects are Bennett, the ex-boyfriend (Adam Trese) of Bennett's daughter (Liz Vassey), and casino owner Caremidi (Richard Beymer).

George Segal plays the well-nicknamed Daffy Dave Navarro, who has recently been acquitted on charges of murdering his first wife. Now Daffy Dave is determined to sue for a generous share of royalties from a book written by Jessica (Angela Lansbury) and purportedly based on his case. But this time, Dave may have overplayed his hand--and another murder is the result.

Jessica (Angela Lansbury) is back in London, there to attend the opening night of a play based on one of her novel's. The play's producer (Robin Sachs) has a reputation for ruthlessness and duplicity, so it really surprises no one when he is murdered. Nor can anyone be surprised when Jessica (Angela Lansbury) takes it upon herself to prove that the play's leading lady (Jean Marsh) is not the murderer.