America Ferrera Betty Suarez Actor Eric Mabius Daniel Meade Actor Tony Plana Ignacio Suarez Actor Ana Ortiz Hilda Suarez Actor Judith Light Claire Meade Actor Christopher Gorham Henry Grubstick Actor Ashley Jensen Christina McKinney Actor Becki Newton Amanda Tanen Actor Michael Urie Marc St. James Actor Mark Indelicato Justin Suarez Actor Rebecca Romijn Alexis Meade Actor Vanessa Williams Wilhelmina Slater Actor Freddy Rodríguez Gio Rossi Guest Star Ava Gaudet Gina Gambarro Guest Star Christian Siriano Himself Guest Star Nina Garcia Herself Guest Star Daniel Davis Dr. Morgan Remus Guest Star Gabrielle Union Renee Slater Guest Star Jeff Clarke Larry Goldfarb Guest Star Jim Jack Waiter Guest Star Luz Elena González Luisa -- Telenovela Segment Guest Star Altaír Jarabo Carmen -- Telenovela Segment Guest Star Valentino Lanus Cruz -- Telenovela Segment Guest Star Victor Noriega Mateo -- Telenovela Segment Guest Star Kristin Quinn Siriano's Model Guest Star Silvio Horta Executive Producer Ben Silverman Executive Producer Salma Hayek Executive Producer Jose Tamez Executive Producer Henry Alonso Myers Writer Matt Shakman Director