1) The condemnation of society towards homosexuality with a main argument: "You think your neighbor is a completely normal person until you hear these kind of things", a superficial sentence stated by people totally devoid of any emotional maturity and with full ignorance about any background behind the curtain.
2) The monster represented by masses that unleash their anger and disapproval towards those who are different from an established majority. The leper represents the scope of people towards difference.
3) The haunting segment containing the final sentence dictated towards the minority, with the use of thought-provoking imagery of deeply symbolic meaning (hence, the spitting sequence is the most brutal by what it stands for).
So, are they poisoning society, or does society is already a poison to anything?
I think I could find a way to link these three stories to sexuality, specifically gay sexuality, just as several other reviewers have done, but the acting and writing were so deplorable that it made it difficult to follow the film. I understand that "Horror," the B-movie storyline, was supposed to have bad acting, but there is no such excuse for the other two stories. The performances were so stilted and self-conscious, and it seemed like first-time director Todd Haynes didn't shoot enough takes.
Overall, I think there might be something interesting underneath the crappy acting, but I couldn't bring myself to see it clearly.