Charles Stone III Director Kyrie Irving Uncle Drew Actor Lil Rel Howery Dax Actor Nick Kroll Mookie Actor Shaquille O'Neal Big Fella Actor Chris Webber Preacher Actor Reggie Miller Lights Actor Nate Robinson Boots Actor Lisa Leslie Betty Lou Actor Erica Ash Maya Actor Tiffany Haddish Jess Actor J.B. Smoove Angelo Actor Mike Epps Louis Actor Jay Longino Screenwriter Marty Bowen Producer Wyck Godfrey Producer Louis Arbetter Executive Producer Aziel Rivers Executive Producer Marc Gilbar Executive Producer Colin Smeeton Executive Producer Perry Rogers Executive Producer Jeffrey Wechsler Executive Producer Erik Feig Executive Producer John Fischer Executive Producer Michael Flynn Executive Producer Mike Upton Executive Producer Karsten Gopinath Cinematographer Jeff Freeman Film Editing Sean Valla Film Editing Christopher Lennertz Original Music Doug J. Meerdink Production Design Mark Garner Art Director Matthew Groves Set Decoration Johnetta Boone Costume Design Victoria Thomas Casting