Patrick Wilson Dr. Michael Holt Actor Jennifer Ehle Anna Paul Actor Margo Martindale Rita Perkins-Hall Actor Pablo Schreiber Anton Little Creek Actor Afton Williamson Autumn Guest Star Rhys Coiro Dr. Zeke Barnes Guest Star Gbenga Akinnagbe Dr. Leo "Bax" Baxter Guest Star Armando Riesco Tavo Guest Star Raúl Esparza Phillip Romero Guest Star Mike Doyle Victor Lantz Guest Star Marin Ireland Elena Guest Star Sue Jean Kim Nurse Collette Guest Star Roslyn Ruff Audrey Lewis Guest Star Brian Kerwin Jim Marks Guest Star Jenna Stern Rebecca Marks Guest Star Eric Ruffin Patrice Lambert Guest Star Teagle F. Bougere Harold Guest Star Isabel Santiago Mother at Holt Guest Star Orlagh Cassidy Joanne Guest Star Brynn O'Malley Liz Martin Guest Star Tom Nelis Man at Clinica Guest Star Charles Turner Mr. Keller Guest Star Susannah Grant Executive Producer Jonathan Demme Executive Producer Sarah Timberman Executive Producer Carl Beverly Executive Producer Neal Baer Executive Producer, Writer Daniel Truly Writer Jonathan Kaplan Director