Patrick Wilson Dr. Michael Holt Actor Jennifer Ehle Anna Paul Actor Margo Martindale Rita Perkins-Hall Actor Pablo Schreiber Anton Little Creek Actor Rachelle Lefevre Dr. Kate Sykora Actor Rhys Coiro Dr. Zeke Barnes Guest Star Afton Williamson Autumn Guest Star Julie Benz Christina Holt Guest Star Tijuana Ricks Nurse Charisse Guest Star Eriq La Salle Evan "E-Mo" Morris Guest Star Adrian Martinez Hector Guest Star Leland Orser Charlie Reinhart Guest Star Dana Wheeler-Nicholson Jayne Reinhart Guest Star Kailani Coba Maribel Lopez Guest Star Sol Miranda Cecilia Gonzales Guest Star Britt Lower Nina Guest Star Susannah Grant Executive Producer Jonathan Demme Executive Producer Sarah Timberman Executive Producer Carl Beverly Executive Producer Neal Baer Executive Producer Lisa Melamed Writer Alison Tatlock Writer Adam Bernstein Director