Amidst a shifting political climate, Frank goes head to head with City Council Speaker Regina Thomas over protests against police brutality. Also, Jamie and his nephew Joe Hill work together to locate Danny and Baez when they go missing while searching for a killer, and Eddie steps up to help an abrasive woman find her father's body after it was misplaced during the outset of the pandemic.

Danny and Jamie combine forces to convict a notorious drug lord, as Erin nervously awaits the Governor's selection for the new District Attorney. Also, Frank and his grandson, Joe Hill, face a difficult decision as they navigate their new and complicated family ties.

After Joe Hill's lineage as a Reagan is revealed, Frank struggles from a distance when his grandson wants to fight his own battles. Meanwhile, Erin and Anthony receive gift-wrapped evidence, and must carefully weigh their options.

Frank must decide whether the department can accommodate a request to remain in the field from Detective Allison Mulaney, a lauded cop who is wheelchair-bound after being wounded in the line of duty. Also, Erin is conflicted by the weight of her authority in the sentencing of a man guilty of vehicular homicide, Danny and Baez pursue a rideshare rapist, and Jamie and Eddie team up to aid a fellow officer when his partner is shot on the job.

Eddie and her partner, Officer Rachel Witten, are heralded for their bravery for stopping an active shooter, until a civilian comes forward to accuse them of faking the incident as part of a government conspiracy. Also, Frank pries into a decades-long history of cash payments his father Henry has been making to an unknown recipient, Danny and Baez find themselves in the middle of a fierce sibling rivalry between two brothers as they investigate the murder of the men's father.

The Reagans confront hard choices on the job when Frank deals with a police captain who's losing his grip over his precinct, and Danny faces backlash from the Baez and Internal Affairs over a tough call he made in the field. Also, Jamie and Eddie are shown the ropes of field crisis management when a social worker is assigned to them for a ride-a-long, and Erin weighs the consequences of a dangerous criminal's release under new bail laws.

After Danny witnesses a drive-by shooting, he butts heads with the detective assigned to the case. Also, a childhood friend of Jamie's is convinced that she has single-handedly solved a cold case murder, and Frank struggles to trust an ex-detective when he brings forth information about a suspected crime ring.

Erin tries not to feel overpowered as her new boss shadows her at work just as she's trying to get a nervous eye-witness to reveal the identity of who shot her boyfriend. Also, the serial killer who previously held Danny and Baez hostage resurfaces, and when Jaime arrests an intrusive reporter who appears at a series of store lootings, it leads to a standoff between Frank and the Attorney General over the press' First Amendment rights.

Baez confides in Danny and asks for his help in proving her innocence after she finds a corpse in her front yard. Also, Erin struggles to find a peaceful solution when she receives harsh case notes from her boss, Jamie and Eddie butt heads over the handling of a young cop's punishment, and Frank makes his whole team attend therapy after Gormley exhibits troubling behavior.

Frank asks Erin to liaise between him and NY Governor Mendez regarding policy reform he privately backs, but can't publicly support, because it goes against police rank and file. Also, Danny and Baez become enmeshed in the world of competitive gaming when a high-profile video game streamer is murdered, and Eddie and Witten suspect a live-in nanny is being abused after she approaches them on the street for help.