Nathan Fillion Richard Castle Actor Stana Katic NYPD Captain Kate Beckett Actor Susan Sullivan Martha Rodgers Actor Molly C. Quinn Alexis Castle Actor Ruben Santiago-Hudson Captain Roy Montgomery Actor Tamala Jones Lanie Parish Actor Jon Huertas NYPD Detective Javier Esposito Actor Seamus Dever NYPD Detective Kevin Ryan Actor Anita Barone Janice Freeman Guest Star Robin Thomas Alan Freeman Guest Star Samantha Shelton Vixen Guest Star Erin Sanders Rosie Freeman Guest Star Phil LaMarr Dr. Holloway Guest Star Amy Hill Alma Guest Star Jim Gleason Dr. Barry Frank Guest Star Andrew W. Marlowe Executive Producer Armyan Bernstein Executive Producer Barry Schindel Executive Producer Rob Bowman Executive Producer Laurie Zaks Executive Producer Terri Miller Writer Karen Gaviola Director