Gary Sinise Det. Mack "Mac" Taylor Actor Sela Ward Jo Danville Actor Carmine Giovinazzo Det. Danny Messer Actor Hill Harper Dr. Sheldon Hawkes Actor Eddie Cahill Det. Donald Flack, Jr. Actor Anna Belknap Det. Lindsay Monroe Messer Actor A.J. Buckley Adam Ross Actor Robert Joy Dr. Sid Hammerback Actor John Larroquette Chief Ted Carver Guest Star Jeffrey Vincent Parise Gordon Sprouse Guest Star Kelly Polk Isabel Wilde Guest Star Lightfield Lewis Declan Sullivan Guest Star Sophia Bui Guest Star Jamie Tisdale Samantha Guest Star Marianne Chambers Lisa Tate Guest Star Anastacia McPherson Helen Guest Star Jerry Bruckheimer Executive Producer Carol Mendelsohn Executive Producer Ann Donahue Executive Producer Anthony Zuiker Executive Producer Danny Cannon Executive Producer Andrew Lipsitz Executive Producer Kim Clements Writer Marshall Adams Director