Gary Sinise Det. Mack "Mac" Taylor Actor Sela Ward Jo Danville Actor Carmine Giovinazzo Det. Danny Messer Actor Hill Harper Dr. Sheldon Hawkes Actor Eddie Cahill Det. Donald Flack, Jr. Actor Anna Belknap Det. Lindsay Monroe Messer Actor A.J. Buckley Adam Ross Actor Robert Joy Dr. Sid Hammerback Actor Lesley-Ann Brandt Camille Jordanson Guest Star Adrienne Barbeau Dr. Theola Kumi Guest Star Brandon Scott William Dowd Guest Star Robert Della Cerra Guest Star Chad Randall George Parker Guest Star Erik Stabenau Julian Grace Guest Star Jeff Barnett Bartender , Ken Marion Guest Star Ne-Yo The Handsome Man Guest Star Jerry Bruckheimer Executive Producer Carol Mendelsohn Executive Producer Ann Donahue Executive Producer Anthony Zuiker Executive Producer Danny Cannon Executive Producer Andrew Lipsitz Executive Producer Aaron Rahsaan Thomas Writer Scott White Director