Gary Sinise Det. Mack "Mac" Taylor Actor Sela Ward Jo Danville Actor Carmine Giovinazzo Det. Danny Messer Actor Hill Harper Dr. Sheldon Hawkes Actor Eddie Cahill Det. Donald Flack, Jr. Actor Anna Belknap Det. Lindsay Monroe Messer Actor A.J. Buckley Adam Ross Actor Robert Joy Dr. Sid Hammerback Actor Natalie Martinez Detective Jamie Lovato Guest Star Sydney Park Ellie Danville Guest Star Peter Horton Cade Conover Guest Star Trent Garrett Oliver Epps Guest Star Christina Scherer Mary Portico Guest Star Rebecca Lowman Sybil Portico Guest Star Blake Robbins Jimmy Portico Guest Star Jullian Dulce Vida Guest Star Colton Shires Guest Star Seidy Lopez Guest Star Erwin Stone Guest Star Sean Harmon Guest Star Jerry Bruckheimer Executive Producer Carol Mendelsohn Executive Producer Ann Donahue Executive Producer Anthony Zuiker Executive Producer Danny Cannon Executive Producer Andrew Lipsitz Executive Producer Trey Callaway Writer Vikki Williams Director