Jonny Lee Miller Sherlock Holmes Actor Lucy Liu Joan Watson Actor Aidan Quinn Captain Thomas Gregson Actor Jon Michael Hill Detective Marcus Bell Actor Michael Weston Oscar Rankin Guest Star Gary Wilmes Robert Barclay Guest Star Lorraine Velez Claudia Sandoval Guest Star Richard Brooks Detective Demps Guest Star Aaron Serotsky Detective McShane Guest Star Tim McGeever Resident Guest Star Felix Solis Prentice Gutierrez Guest Star Sarah Quinn Assistant Guest Star Doreen Montalvo Nurse Guest Star Jessica Diaz Maria Gutierrez Guest Star Keira Keeley Guitar Woman Guest Star Robert Doherty Executive Producer Carl Beverly Executive Producer Sarah Timberman Executive Producer Craig Sweeny Executive Producer Peter Ocko Writer Guy Ferland Director