Jonny Lee Miller Sherlock Holmes Actor Lucy Liu Joan Watson Actor Aidan Quinn Captain Thomas Gregson Actor Jon Michael Hill Detective Marcus Bell Actor Desmond Harrington Michael Actor Jordan Gelber ME Hawes Guest Star Brett Dalton Ryan Hayes Guest Star Trieste Kelly Dunn Sophie Bush Guest Star Wayne Wilcox Drew Bishop Guest Star Geoffrey Owens Vernon Fisk Guest Star Ricky Garcia Ramon Guest Star J. Oscar Simmons Foreman Guest Star Trevor Van Uden Sammy Olivetti Guest Star Summer Sveinson Bethany Marshall Guest Star Robert Doherty Executive Producer Carl Beverly Executive Producer Sarah Timberman Executive Producer John Polson Executive Producer Jason Tracey Executive Producer Bob Goodman Writer Christine Moore Director