Seth MacFarlane Peter Griffin as Joseph , Stewie Griffin as Jesus , Brian Griffin as Robby , Glenn Quagmire as Wise Man , Carter Pewterschmidt as King Herod , Dr. Elmer Hartman , God Voice, Executive Producer Alex Borstein Lois Griffin as Mary Voice Seth Green Chris Griffin as Drummer Boy Voice Mila Kunis Meg Griffin as Donkey Voice Mike Henry Cleveland Brown as Wise Man , Consuela as Virginity Coach , Bruce the Performance Artist as Angel Gabriel Voice Patrick Warburton Joe Swanson as Wise Man Voice Ryan Reynolds Overweight Guy Guest Voice Johnny Brennan Mort Goldman as Innkeeper Guest Voice Alec Sulkin Jesus Christ Guest Voice Ellen Albertini Dow Aunt Helen Guest Voice Christine Lakin Joyce Kinney Guest Voice Stephanie Escajeda Additional Voices Guest Voice Ralph Garman Additional Voices Guest Voice Gary Janetti Additional Voices Guest Voice Cleo King Additional Voices Guest Voice Bruce McGill Additional Voices Guest Voice Catherine Reitman Additional Voices Guest Voice Julius Sharpe Additional Voices Guest Voice Danny Smith Additional Voices Guest Voice John Viener Additional Voices Guest Voice David Zuckerman Executive Producer Julius Wu Director Dominic Bianchi Director James Purdum Director