Kelsey Grammer Dr. Frasier Crane Actor, Executive Producer, Director John Mahoney Martin Crane Actor Jane Leeves Daphne Moon Actor David Hyde Pierce Dr. Niles Crane Actor Peri Gilpin Roz Doyle Actor Victor Garber Ferguson Guest Star Jane Adams Dr. Mel Karnofsky Guest Star Nicholas Hormann Alan Murchie Guest Star Francis Guinan Ted Fisher Guest Star Noel Conlon Henry Worth Guest Star B.J. Ward Diane Murchie Guest Star David Angell Executive Producer Peter Casey Executive Producer David Lee Executive Producer Mark Reisman Executive Producer Dan O'Shannon Executive Producer Sam Johnson Writer Chris Marcil Writer