Kelsey Grammer Dr. Frasier Crane Actor, Executive Producer John Mahoney Martin Crane Actor Jane Leeves Daphne Moon Actor David Hyde Pierce Dr. Niles Crane Actor Peri Gilpin Roz Doyle Actor Trevor Einhorn Frederick Crane Guest Star Michael Philip Dr. Jack Betcher Guest Star Richard Gleason Ted AKA Hans Guest Star Melissa Etheridge Cleo Guest Voice David Angell Executive Producer Peter Casey Executive Producer David Lee Executive Producer Mark Reisman Executive Producer Dan O'Shannon Executive Producer Sheldon Epps Director Lori Kirkland Baker Writer