Kelsey Grammer Dr. Frasier Crane Actor, Executive Producer John Mahoney Martin Crane Actor Jane Leeves Daphne Moon Actor David Hyde Pierce Dr. Niles Crane Actor Peri Gilpin Roz Doyle Actor Jennifer Coolidge Frederica Guest Star Charles Cioffi Endicott Guest Star David Norona Lance Guest Star Jonathan McMurtry Reynolds Guest Star Richard Stretchberry Virgil Hefflewhite Guest Star Edward Hibbert Gil Chesterton Guest Star David Angell Executive Producer Peter Casey Executive Producer David Lee Executive Producer Mark Reisman Executive Producer Dan O'Shannon Executive Producer Pamela Fryman Director David Lloyd Writer