Ellen Pompeo Dr. Meredith Grey Actor Patrick Dempsey Dr. Derek Shepherd Actor James Pickens Jr. Dr. Richard Webber Actor T.R. Knight Dr. George O'Malley Actor Sandra Oh Dr. Cristina Yang Actor Katherine Heigl Dr. Izzie Stevens Actor Chandra Wilson Dr. Miranda Bailey Actor Isaiah Washington Dr. Preston Burke Actor Justin Chambers Dr. Alex Karev Actor Kate Burton Guest Star Alice Lo Guest Star Scarlett Lam Guest Star Robin Pearson Rose Guest Star Kerry Carney Guest Star Dennis Gubbins Guest Star Kerri Higuchi Guest Star Stephen Blackehart Guest Star Stacey Hinnen Guest Star Elise Robertson Guest Star Kylie Dragna Guest Star Gary Kraus Guest Star Sonia Jackson Guest Star Wally Rudolph Guest Star Scott Michael Morgan Guest Star Cindy Drummond Guest Star Shonda Rhimes Executive Producer, Writer Mark Gordon Executive Producer Betsy Beers Executive Producer James D. Parriott Executive Producer Peter Horton Director