Ellen Pompeo Dr. Meredith Grey Actor Patrick Dempsey Dr. Derek Shepherd Actor Sandra Oh Dr. Cristina Yang Actor Isaiah Washington Dr. Preston Burke Actor Katherine Heigl Dr. Izzie Stevens Actor Justin Chambers Dr. Alex Karev Actor T.R. Knight Dr. George O'Malley Actor Chandra Wilson Dr. Miranda Bailey Actor James Pickens Jr. Dr. Richard Webber Actor Bruce Weitz Guest Star Alex Alexander Guest Star Jane Galloway Heitz Guest Star Lara Phillips Guest Star Steven W. Bailey Guest Star Patricia Bethune Guest Star Yvonne Farrow Guest Star John O'Brien Guest Star Yolanda Snowball Guest Star Wally Rudolph Guest Star Moe Irvin Guest Star Noelle McCutchen Guest Star Sharmila Devar Guest Star Shonda Rhimes Executive Producer Mark Gordon Executive Producer Betsy Beers Executive Producer James D. Parriott Executive Producer Krista Vernoff Writer Scott Brazil Director